Clinical development of micelle-forming polymeric drug

Development of an MMP2-Sensitive Folate Receptor (FR)-Targeted Polymeric Micelle for Tumor- Targeted Drug Delivery and Cancer Sensitization

A fully absorbable biomimetic polymeric micelle loaded with cisplatin as drug carrier for cancer therapy

cis-dichlorodiammineplatinum(II) (CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP. Herein, polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly (L-glutamic acid)-b-poly (2-methacryloyloxyethyl phosphorylcholine) (PLG-b-PMPC) diblock copolymers. These CDD...

Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers.

Amphiphilic ABC triblock copolymers composed of monomethoxy-capped poly(ethylene glycol) (MPEG), poly(2-(dimethylamino)ethyl methacrylate) (DMA), and poly(2-(diethylamino)ethyl methacrylate) (DEA) have been synthesized by atom transfer radical polymerization (ATRP). These copolymers dissolve molecularly in acidic aqueous media at room temperature due to protonation of the tertiary amine groups ...

Clinical Applications of Polymeric Micelle Carrier Systems in Chemotherapy and Image Diagnosis of Solid Tumors

Please cite this article in press as: Yokoya Diagnosis of Solid Tumors, Journal of Exper Polymeric micelles are assemblies of synthetic polymers and have been studied and developed as drug carriers for targeting solid tumors. Physicochemical characters and medical advantages of the polymeric micelle carrier systems are summarized, followed by an explanation of their recent application for contr...

Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.

Adriamycin (ADR), an anthracycline anticancer drug, was bound to the poly(aspartic acid) chain of poly(ethylene glycol)-poly(aspartic acid) block copolymer by amide bond formation between an amino group of Adriamycin and the carboxyl groups of the poly(aspartic acid) chain. The polymeric drug thus obtained was observed to form a micelle structure possessing diameter of approximately 50 nm, with...